Background: Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed
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The impact of chromosomal fusions on 3D genome folding and recombination in the germ lineThe impact of chromosomal fusions on 3D genome folding and recombination in the germ line
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The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of