R4RL2 rabbit pAb - 50 μL

Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. PTM: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. similarity: Belongs to the Nogo receptor family. similarity: Contains 8 LRR (leucine-rich) repeats. subcellular location: Localized to the surface of neurons, including axons. tissue specificity: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.