Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the reg µLation of cell proliferation, differentiation and migration, and in reg µLation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-reg µLation of the expression of CYP7A1 the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cell µLar signaling molec µLes diacylglycerol and inositol 14,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1 PIK3R1 and SOS1 and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-reg µLated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
Immunogen : fibroblast growth factor receptor 4
Aliases : CD334, FGFR 4, FGFR4, JTK2, TKF
Observed MW : 100-110 kDa
Uniprot ID : P22455
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 200-1 : 1000; IHC : 1 : 50-1 : 500
Gene ID : 2264
Research Area : Signal Transduction, Metabolism, Cardiovasc µLar, Immunology, Cancer, Developmental biology, Stem Cells