p53RFP rabbit pAb - 100 μL

Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. pathway: Protein modification; protein ubiquitination. PTM: Auto-ubiquitinated. similarity: Belongs to the RBR family. RNF144 subfamily. similarity: Contains 1 IBR-type zinc finger. similarity: Contains 2 RING-type zinc fingers. subunit: Interacts with UBE2L3, UBE2L6 and LCMT2. tissue specificity: Broadly expressed, with lowest levels in brain, spleen and thymus.