MMP8 (Cleaved-Leu101) rabbit pAb - 100 μL

Catalytic activity: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3. 4. 24. 7, this enzyme cleaves type III collagen more slowly than type I. Cofactor: Binds 2 zinc ions per subunit. Cofactor: Binds 3 calcium ions per subunit. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. enzyme regulation: Cannot be activated without removal of the activation peptide. function: Can degrade fibrillar type I, II, and III collagens. similarity: Belongs to the peptidase M10A family. similarity: Contains 4 hemopexin-like domains. subcellular location: Stored in intracellular granules. tissue specificity: Neutrophils.