pMEV2HA-P38-K53M

Human P38 Xpress Clones Mitogen-activated protein kinases (MAPKs) cascade relays extracellular signals from cell membrane to the nucleus to induce intracellular responses and to regulate many aspects of cell physiology. These cascades, including JNK, ERK and p38 pathways, consist of distinct members of regulatory enzymes that serially activate one another in response to growth factors, cytokines and other mitogenic stimuli, leading to (in)activation of transcription factors. Proinflammatory cytokine and microbial products activate p38 (SAPK2) gene regulating pathway and cause the expression of multiple cytokine genes including IL-1, IL-6 and TNF alpha. The mutation p38 K53M renders the enzyme catalytically inactivate.Gene Name: Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1. - 20 ug