pMEV2HA-IRAK1-KA

Human IRAK1 Xpress Clones Interleukin-1 receptor-associated kinases (IRAK), identified as a serine/threonine kinases coprecipitated with IL-1 receptor (IL-1R) in an IL-1 inducible manner, share significant homology to pelle. The mammalian family of IRAK consists of two active kinases, IRAK-1 and IRAK-4; and two inactive kinases, IRAK-2 and IRAK-M. They are implicated in the TLR/IL-1R pathway to both IKK and MAPKs activation, leading to the activation of transcription factors like NF-κB and AP-1.Human IRAK-1 gene (NM_001569) encodes a protein of 90kDa in a wide variety of tissues Like other IRAKs, IRAK-1 is a multidomain protein, consisting of N-terminal death domain (DD) and a central kinase domain (KD). Mutation in the ATP binding pocket, K239A renders the enzyme catalytically inactive. - 20 ug