pMEV2HA-NRAS-S17N

Human NRAS Xpress Clones Ras proteins are members of small GTPase superfamily. They bind GDP/GTP and possess intrinsic GTPase activity. These proteins act as switches to turn on/off their downstream target proteins in response to upstream stimuli because they can alternate between an inactive form bound to GDP and an active form bound to GTP. Human NRAS cDNA was first cloned from human sarcoma cell lines (HT1080 and RD). Activating mutations of NRAS at codons 12, 13 or 62 were found in a variety of human tumors. S17N is a widely used dominant negative mutant.Gene Name: Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog. Other Names: N-ras; NRAS1; neuroblastoma RAS viral (v-ras) oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog; Transforming protein N-Ras. - 20 ug