EDG-8 rabbit pAb - 50 μL

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e. g. EDG1; MIM 601974) are S1P receptors; others (e. g. EDG2; MIM 602282) are LPA receptors. [supplied by OMIM, Mar 2008],