Volume : 50 µg
Clone Number :
Aliases : Coding region determinant-binding protein antibody; CRD BP antibody; CRD-BP antibody; CRDBP antibody; IF2B1 antibody; IF2B1_HUMAN antibody; IGF II mRNA binding protein 1 antibody; IGF-II mRNA-binding protein 1 antibody; IGF2 mRNA binding protein 1 antibody; IGF2 mRNA-binding protein 1 antibody; IGF2BP1 antibody; IMP 1 antibody; IMP-1 antibody; IMP1 antibody; Ins µLin like growth factor 2 mRNA binding protein 1 antibody; Ins µLin-like growth factor 2 mRNA-binding protein 1 antibody; VICKZ family member 1 antibody; VICKZ1 antibody; ZBP 1 antibody; ZBP-1 antibody; ZBP1 antibody; Zip code binding protein 1 antibody; Zip code-binding protein 1 antibody; Zipcode binding protein 1 antibody; Zipcode-binding protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NZI8
Immunogen : Recombinant Human Ins µLin-like growth factor 2 mRNA-binding protein 1 protein (440-534AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript \'caging\' into mRNPs allows mRNA transport and transient storage. It also mod µLates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in ad µLt sensory neurons (By similarity). Reg µLates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3\'-UTR, known as the \'zipcode\'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key reg µLator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably thro µgh the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May reg µLate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3\'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and reg µLates IGF2 mRNA subcell µLar localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3\'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and reg µLates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoreg µLatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stim µLated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracell µLar signaling networks. Binds to MAPK4 3\'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-reg µLation) and PTEN (up-reg µLation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1 allowing F-actin polymerization. Hence enhances the velocity of cell migration and stim µLates directed cell migration by PTEN-mod µLated polarization. Interacts with Hepatitis C virus (HCV) 5\'-UTR and 3\'-UTR and specifically enhances translation at the HCV IRES, but not 5\'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cell µLar membranes. During cell µLar stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress gran µLes, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IGF2BP1
Research Areas : Epigenetics and Nuclear Signaling
