Volume : 50 µg
Clone Number :
Aliases : Adipocyte membrane protein antibody; BDPLT10 antibody; CD36 antibody; CD36 antigen (collagen type I receptor, thrombospondin receptor) antibody; CD36 antigen antibody; CD36 molec µLe (thrombospondin receptor) antibody; CD36 molec µLe antibody; CD36_HUMAN antibody; CHDS7 antibody; Cluster determinant 36 antibody; Collagen receptor, platelet antibody; FAT antibody; Fatty acid translocase antibody; Fatty acid transport protein antibody; Glycoprotein IIIb antibody; GP IIIb antibody; GP3B antibody; GP4 antibody; GPIIIB antibody; GPIV antibody; Leukocyte differentiation antigen CD36 antibody; MGC108510 antibody; MGC91634 antibody; PAS 4 protein antibody; PAS IV antibody; PAS-4 antibody; PASIV antibody; Platelet collagen receptor antibody; Platelet glycoprotein 4 antibody; Platelet glycoprotein IV antibody; scarb3 antibody; Scavenger receptor class B member 3 antibody; SR-B3 antibody; SRB3 antibody; Thrombospondin receptor antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P16671
Immunogen : Recombinant Human Platelet glycoprotein 4 protein (191-376AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : M µLtifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally m µLtivalent and can therefore engage m µLtiple receptors sim µLtaneously, the res µLting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cell µLar responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed : 18353783, PubMed : 21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly thro µgh the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed : 18753675). Involved in oral fat perception and preferences (PubMed : 22240721 PubMed : 25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracell µLare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the reg µLation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4 : TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4 : TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1 CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, thro µgh the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed : 20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2 : TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed : 16880211).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CD36
Research Areas : Cancer; Cardiovasc µLar; Immunology; Metabolism; Microbiology; Stem cells
