Volume : 50 µg
Clone Number :
Aliases : 6030405P19Rik antibody; AI429776 antibody; B830038C02Rik antibody; Brain and reproductive organ expressed (TNFRSF1A mod µLator) antibody; brain and reproductive organ expressed protein antibody; Brain and reproductive organ-expressed protein antibody; BRCA1 A complex subunit BRE antibody; BRCA1-A complex subunit BRE antibody; BRCA1/BRCA2 containing complex subunit 4 antibody; BRCA1/BRCA2 containing complex subunit 45 antibody; BRCA1/BRCA2-containing complex subunit 45 antibody; BRCC4 antibody; BRCC45 antibody; bre antibody; BRE_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NXR7
Immunogen : Recombinant Human BRISC and BRCA1-A complex member 2 protein (94-383AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Component of the BRCA1-A complex, a complex that specifically recognizes \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX (PubMed : 17525341 PubMed : 19261746, PubMed : 19261749, PubMed : 19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and mod µLating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed : 21282113, PubMed : 19261748). Component of the BRISC complex, a m µLtiprotein complex that specifically cleaves \'Lys-63\'-linked ubiquitin in various substrates (PubMed : 19214193, PubMed : 24075985, PubMed : 25283148, PubMed : 26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed : 21282113). The BRISC complex is required for normal mitotic spindle assembly and microtub µLe attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed : 26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed : 24075985). Down-reg µLates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed : 24075985). May play a role in homeostasis or cell µLar differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May reg µLate TNF-alpha signaling thro µgh its interactions with TNFRSF1A; however these effects may be indirect (PubMed : 15465831).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BABAM2
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology