HLA-DP/-DQ/-DR (MHC II)(CR3/43) , Biotin conjugate , 0.1mg / mL

Reacts with a common epitope of human major histocompatibility (MHC) class II antigens , HLA-DP , -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes , monocytes , macrophages , and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci , DR , DQ and DP , encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They , therefore , have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_