BAM32 (phospho Tyr139) rabbit pAb - 50 μL

Function: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. induction: Upon B-cell activation. PTM: Phosphorylated on tyrosine residues. similarity: Contains 1 PH domain. similarity: Contains 1 SH2 domain. subcellular location: Membrane-associated after cell stimulation leading to its translocation. subunit: Interacts with PtdIns (3, 4, 5)P3 and PLCG2. In vitro, interacts with PtdIns (3, 4)P2. tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.