Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Amphireg µLin(AREG) is one of the ligands of the epidermal growth factor receptor(EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is syntheVolumed as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in m µLtiple cell µLar and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms(PMID : 9642297).
Immunogen : amphireg µLin
Aliases : Amphireg µLin, AR, AREG, AREGB, CRDGF, SDGF
Observed MW : 43 kDa
Uniprot ID : P15514
Reactivity : Human
Application : ELISA, IF, WB, IHC, FC, IP
Recommended dilution : WB : 1 : 200-1 : 2000; IHC : 1 : 50-1 : 500; IP : 1 : 1000-1 : 10000; IF : 1 : 10-1 : 100
Gene ID : 374
Research Area : Immunology, Cardiovasc µLar, Signal Transduction