WWTR1 rabbit pAb - 50 μL

Domain: Binds to transcription factors via its WW domain. Domain: The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes. function: Functions as a transcriptional coactivator. PTM: Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. similarity: Contains 1 WW domain. subcellular location: Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. subunit: Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. tissue specificity: Highly expressed in kidney, heart, placenta and lung.