Sgo2 rabbit pAb - 50 μL

Function: During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Belongs to the shugoshin family. subcellular location: In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. subunit: Directly interacts with PPP2CA.