C/EBP β (Acetyl Lys265) rabbit pAb - 50 μL

Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. PTM: Sumoylated by polymeric chains of SUMO2 or SUMO3. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. C/EBP subfamily. similarity: Contains 1 bZIP domain. subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. tissue specificity: Expressed at low levels in the lung, kidney and spleen.