CdcA3 rabbit pAb - 50 μL

Domain: The KEN box is required for the association with the APC/C-Cdh1 complex. function: F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase. pathway: Protein modification; protein ubiquitination. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Ubiquitinated and degraded by the APC/C-Cdh1 complex. subunit: Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.