Synaptophysin (Neuroendocrine Marker)(SYP/3551) , Biotin conjugate , 0.1mg / mL

This monospecific monoclonal antibody recognizes a protein of 38 kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse , finely granular , cytoplasmic staining is observed , which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent , broad-range marker of neural and neuroendocrine differentiation. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.