CD40 / TNFRSF5 / CD40L-Receptor (C40/2383) , Biotin conjugate , 0.1mg / mL

CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching , memory B cell development , and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand , which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation , and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes , follicular dendritic cells , bone marrow-derived dendritic cells , thymic epithelium , and interdigitating cells in the T-cell zones of secondary lymphoid organs.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.