B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788) , Biotin conjugate , 0.1mg / mL

B7-H4 (B7-homolog 4) , belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells , B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes , thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies , including ovarian and breast cancer , as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that , similar to Mucin 16 (CA-125) , B7-H4 may be a useful biomarker for the early detection of ovarian cancer. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.