c-Myc Oncoprotein(MYC275 + MYC909) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a transcription factor of 64-67 kDa , identified as c-myc. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or over-expressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease. Rearrangement of the MYC gene is found in 3% to 16% of diffuse large B-cell lymphoma (DLBCL's) and in nearly 100% of Burkitt lymphomas (BL). Identifying MYC status is important in establishing final diagnosis of DLBCL , BL , or B-cell lymphoma , with features intermediate between DLBCL and BL as well as in differential diagnoses of the lymphomas.