PCSK9 rabbit pAb - 50 μL

Cofactor: Calcium. Disease: Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM: 603776]. FH3 inheritance is autosomal dominant. enzyme regulation: Inhibited by EGTA. function: May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. similarity: Belongs to the peptidase S8 family. similarity: Contains 1 peptidase S8 domain. subunit: The precursor protein but not the mature protein may form multimers. tissue specificity: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.