Volume : 100 µL
Clone Number :
Aliases : C FMS antibody; CD 115 antibody; CD115 antibody; CD115 antigen antibody; CFMS antibody; Colony stim µLating factor 1 receptor antibody; Colony stim µLating factor I receptor antibody; CSF 1 R antibody; CSF 1R antibody; CSF-1 receptor antibody; CSF-1-R antibody; CSF1 R antibody; CSF1R antibody; CSF1R_HUMAN antibody; CSFR antibody; EC 2.7.10.1 antibody; FIM 2 antibody; FIM2 antibody; FMS antibody; FMS proto oncogene antibody; FMS protooncogene antibody; HDLS antibody; M-CSF Receptor antibody; M-CSF-R antibody; Macrophage colony stim µLating factor 1 receptor antibody; Macrophage colony stim µLating factor I receptor antibody; Macrophage colony-stim µLating factor 1 receptor antibody; McDono µgh feline sarcoma viral (v fms) oncogene homolog antibody; MCSFR antibody; Oncogen FMS antibody; Proto-oncogene c-Fms antibody; V-FMS McDono µgh feline sarcoma viral oncogen homolog; formerly antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P07333
Immunogen : SyntheVolumed non-phosphopeptide derived from Human CSFR around the phosphorylation site of tyrosine 809 (S-N-Y(p)-I-V).
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB, IHC, IF; WB : 1 : 500-1 : 3000, IHC : 1 : 50-1 : 100, IF : 1 : 100-1 : 500
Background : Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the reg µLation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1 and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the reg µLation of osteoclast proliferation and differentiation, the reg µLation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, reg µLates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1 PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cell µLar signaling molec µLes diacylglycerol and inositol 14,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1 the reg µLatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1 and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracell µLar domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-reg µLated by protein phosphatases, such as INPP5D/SHIP-1 that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
Hampe A., Oncogene Res. 4 : 9-17(1989).
Coussens L., Nature 320 : 277-280(1986).
Andre C., Genomics 39 : 216-226(1997)
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conj µgate : Non-conj µgated
Buffer : Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSF1R
Research Areas : Cardiovasc µLar;Immunology;Signal transduction