gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) (PMEL/2038) , Biotin conjugate , 0.1mg / mL

Cytotoxic T lymphocytes (CTLs) recognize melanoma-associated antigens , which belong to three main groups. These groups include tumor-associated testis-specific antigens , melanocyte differentiation antigens and mutated or aberrantly expressed antigens , which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100 , also designated ME20-M , ME20-S and PMEL 17 , is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues , but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage , which results in a secreted protein.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.