CD54 / ICAM-1(F4-31C2) , Biotin conjugate , 0.1mg / mL

Recognizes an 85-115 kDa protein (variation with cell type) , identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family , present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts , EC , macrophages , and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule , LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors.