Fibronectin Bovine

Fibronectin is a glycoprotein involved in cell adhesion, migration, tissue repair, embryogenesis, and blood clotting. It exists in two main forms: an insoluble extracellular matrix (ECM) dimer produced by various cell types (fibroblasts, chondrocytes, endothelial cells, macrophages, and some epithelial cells), and a soluble plasma dimer synthesized by hepatocytes. Elevated plasma fibronectin levels are associated with severe coronary artery disease and an increased risk of venous thromboembolism (particularly in males), linking it to arterial atherothrombosis. Fibronectin functions as a key adhesion molecule, anchoring cells to collagen or proteoglycans and coordinating interactions between cells and ECM components through specific cell-surface receptors. - 1mg