Rabaptin-5α rabbit pAb - 50 μL

Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. PTM: Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity. similarity: Belongs to the rabaptin family. subunit: Heterodimer with RABGEF1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2.