Rab11-FIP2 rabbit pAb - 50 μL

Function: A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3, 4, 5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). similarity: Contains 1 C2 domain. subcellular location: Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. subunit: Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with RAB11A/RAB11B that has been activated by GTP binding.