IL-1β rabbit pAb - 50 μL

The protein encoded by this gene is a member of the interleukin 1 Cytokine family. This Cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This Cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this Cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a Cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008],