CD40 , Mouse(FGK45.5) , Biotin conjugate , 0.1mg / mL

Upon binding to its ligand CD154 , CD40 acts as a costimulatory molecule for the activation of B cells , dendritic cells , monocytes , and other APCs. CD40 plays roles in B cell activation , differentiation , proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4. 5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells , producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.