IL-4 / Interleukin 4(IL4/1597) , Biotin conjugate , 0.1mg / mL

Interleukin-4 (IL-4) , also designated B cell stimulatory factor-1 , is a glycosylated cytokine secreted by activated T lymphocytes , basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2 , TNF , while Th2 cells secrete IL-4 , IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells , but suppress the production of IgM , IgA , IgG1 , IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4 , but is not detectably phosphorylated following stimulation with IL-2 , IL-12 or erythropoietin._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_